Description
Tolterodine tartrate 2mg/4mg online
Tolterodine Tartrate Tablet acts as a competitive antagonist of acetylcholine at postganglionic muscarinic receptors. Both urinary bladder contraction and salivation are mediated via cholinergic muscarinic receptors. Tolterodine, Is considered an effective & trusted 1st. line treatment option for reducing urinary leakage & other symptoms of OAB with better tolerability than Oxybutynin & Solifenacin. Combination of Tolterodine and Tamsulosin in BPH patients can relieve the patients from refractory LUTS more than Tamsulosin alone. Combined group treated with Tolterodine and Terazosin can improve the IPSS, without any negative effects on the uroflow rate and residual urine. For the treatment of overactive bladder with symptoms of urge urinary incontinence, urinary incontinence, urgency, and frequency.
Tolterodine Tartrate has a pronounced effect on bladder function. Effects on urodynamic parameters before and 1 and 5 hours after a single 6.4 mg dose of tolterodine immediate release were determined in healthy volunteers. The main effects of tolterodine at 1 and 5 hours were an increase in residual urine, reflecting an incomplete emptying of the bladder, and a decrease in detrusor pressure. These findings are consistent with an antimuscarinic action on the lower urinary tract. Tolterodine is a competitive muscarinic receptor antagonist. Both urinary bladder contraction and salivation are mediated via cholinergic muscarinic receptors. After oral administration, tolterodine is metabolized in the liver, resulting in the formation of the 5-hydroxymethyl derivative, a major pharmacologically active metabolite.
The 5-hydroxymethyl metabolite, which exhibits an antimuscarinic activity similar to that of tolterodine, contributes significantly to the therapeutic effect. Both tolterodine and the 5-hydroxymethyl metabolite exhibit a high specificity for muscarinic receptors, since both show negligible activity or affinity for other neurotransmitter receptors and other potential cellular targets, such as calcium channels.
Pack style: 56 Film-coated Tablets or as per customer specification.
