Description
Talzenna (Talazoparib) 1mg Online
Talzenna (Talazoparib) is a chemotherapy drug. It targets specific enzymes within cancer cells and stops the cancer cell from growing. This medicine is used to treat breast cancer. And also are used to treat certain types of cervical cancer. They prevent the tumor’s DNA from repairing itself properly, in order to target and kill cancer cells. Talzenna is used to treat certain types of breast cancer that has spread within the breast or to other areas of the body. Talzenna is in a class of medications called poly (ADP-ribose) polymerase (PARP) inhibitors. It works by stopping or slowing the growth of cancer cells.
Talzenna is an inhibitor of PARP enzymes, PARP1, and PARP2. PARP enzymes are involved in cellular DNA damage response signalling pathways such as DNA repair, gene transcription, and cell death. PARP inhibitors (PARPi) exert cytotoxic effects on cancer cells by 2 mechanisms, inhibition of PARP catalytic activity and by PARP trapping, whereby PARP protein bound to a PARPi does not readily dissociate from a DNA lesion, thus preventing DNA repair, replication, and transcription, thereby resulting in apoptosis and/or cell death. Treatment of cancer cell lines that are harbouring defects in DNA repair genes with talazoparib single-agent leads to increased levels of γH2AX, a marker of double-stranded DNA breaks, and results in decreased cell proliferation and increased apoptosis. Talazoparib anti-tumour activity was also observed in a patient-derived xenograft (PDX) BRCA mutant breast cancer model where the patient was previously treated with a platinum-based regimen. In this PDX model, talazoparib decreased tumour growth and increased γH2AX level and apoptosis in the tumours.
Talzenna comes as a capsule to take by mouth. It is usually taken with or without food once a day. Take Talzenna at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take talazoparib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
