Description
Oxycodone Hydrocloride 50mg/1ml Solution for injection or infusion Online
Oxycodone hydrochloride is an analgesic drug, which is generally used in cancer treatment since it can reduce the pain induced during the treatment. Oxycodone Hydrochloride 50 mg/ml solution for injection /infusion, undiluted or diluted to 3 mg/ml with 0.9% w/v saline, 5% w/v dextrose or water for injections, is physically and chemically stable when in contact with representative brands of polypropylene or polycarbonate syringes, polyethylene or PVC tubing, and PVC or EVA infusion bags, over a 24 hour period at 25°C.
Inappropriate handling of the undiluted solution after the opening of the original ampoule, or of the diluted solutions may compromise the sterility of the product. The 50 mg/ml injection, whether undiluted or diluted to 3 mg/ml in the infusion fluids and containers detailed above, does not need to be protected from light over a 24 hour period.
Oxycodone is indicated in adults for the treatment of moderate to severe pain in patients with cancer and post-operative pain. The treatment of severe pain requires the use of a strong opioid. Dilute in 0.9% saline, 5% dextrose, or water for injections if required. A starting dose of 7.5 mg/day is recommended in opioid naïve patients, titrating gradually according to symptom control. Cancer patients transferring from oral oxycodone may require much higher doses.
The dose initiation should follow a conservative approach in these patients. The recommended adult starting dose should be reduced by 50% (for example a total daily dose of 10 mg orally in opioid naïve patients), and each patient should be titrated to adequate pain control according to their clinical situation. Opioids are not first-line therapy for chronic non-malignant pain, nor are they recommended as the only treatment. Types of chronic pain that have been shown to be alleviated by strong opioids include chronic osteoarthritic pain and intervertebral disc disease. The need for continued treatment in non-malignant pain should be assessed at regular intervals.
